FNDC3A

Chr 13

fibronectin type III domain containing 3A

Also known as: FNDC3, HUGO, bA203I16.1, bA203I16.5

NCBI Gene: 22862 ENSG00000102531 UniProt: Q9Y2H6

This protein mediates spermatid-Sertoli cell adhesion during spermatogenesis and has RNA binding activity. The gene is highly constrained against loss-of-function variants (pLI = 1.0, LOEUF = 0.22), but no human disease associations have been established in the provided data.

ResearchSummary from RefSeq, UniProt

Enables RNA binding activity. Predicted to be involved in spermatid development. Predicted to act upstream of or within Sertoli cell development; cell-cell adhesion; and fertilization. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

—

P/LP submissions

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P/LP missense

0.22

LOEUF· LoF intol.

LOF

Mechanism· predicted

Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429