FIRRM

Chr 1

FIGNL1 interacting regulator of recombination and mitosis

Also known as: Apolo1, C1orf112, FLIP, MEICA1

NCBI Gene: 55732ENSG00000000460UniProt: Q9NSG2OMIM: 621430

Enables protein kinase binding activity. Involved in several processes, including chromosome segregation; interstrand cross-link repair; and regulation of protein kinase activity. Located in several cellular components, including midbody; nuclear lumen; and spindle midzone. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
3
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.73
LOEUF
—
Mechanism

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.73LOEUF
pLI 0.000
Z-score 3.00
OE 0.52 (0.37–0.73)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
0.57Z-score
OE missense 0.92 (0.85–1.00)
396 obs / 429.4 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.52 (0.37–0.73)
0≤0.351.4
Missense OE?0.92 (0.85–1.00)
0≤0.61.4
Synonymous OE?0.91
0≤1.21.6
LoF obs/exp: 23 / 44.6Missense obs/exp: 396 / 429.4Syn Z: 0.89

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

FIRRM · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients