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FIMP1

Chr 16

fertilization-influencing membrane protein 1

Also known as: C16orf92, FIMP

NCBI Gene: 146378 OMIM: 618911

The protein is predicted to be involved in sperm-egg membrane fusion during fertilization and is located in the plasma membrane. Currently, no human diseases have been definitively associated with mutations in this gene. The inheritance pattern for any potential disorders would likely follow autosomal patterns, though clinical significance remains to be established.

OMIM ResearchSummary from RefSeq

Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

OMIM ResearchGenerating clinical summary…

Clinical Summary— FIMP1

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ClinVar Variants

1 unique Pathogenic / Likely Pathogenic· 19 VUS of 26 total submissions

Explore recent and relevant literature in Research Assistant →

Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for /lookup/symbol/homo_sapiens/FIMP1?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

26 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic1

VUS19

Likely Benign5

Pathogenic

VUS

Likely Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

Classification	LoF	Missense + Inframe	Synonymous	Total
Pathogenic	1	0	0	1
Likely Pathogenic	0	0	0	0
VUS	1	18	0	19
Likely Benign	0	2	3	5
Benign	0	0	0	0
Total	2	20	3	25

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

32 pathogenic / likely-pathogenic (of 34) ClinVar copy-number / structural variants overlap FIMP1 — these span large chromosomal regions, not the gene specifically, and are excluded from the counts above. Explore in CNV tools →