FIGNL2
Chr 12fidgetin like 2
The FIGNL2 protein functions as a microtubule-severing enzyme that hydrolyzes ATP to cut microtubules at the cell leading edge, thereby negatively regulating cell migration and axon regeneration. Based on the provided information, no specific diseases or inheritance patterns associated with FIGNL2 mutations have been established. The pathogenic mechanism would likely involve disrupted microtubule dynamics affecting cellular motility and potentially neuronal development.
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
25 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 7 | 0 | 7 |
Likely Pathogenic | 0 | 0 | 1 | 0 | 1 |
VUS | 0 | 12 | 3 | 0 | 15 |
Likely Benign | 0 | 0 | 0 | 0 | 0 |
Benign | 0 | 0 | 0 | 0 | 0 |
| Total | 0 | 12 | 11 | 0 | 23 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
FIGNL2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools