FGFBP3

Chr 10

fibroblast growth factor binding protein 3

Also known as: C10orf13, FGF-BP3

NCBI Gene: 143282ENSG00000174721UniProt: Q8TAT2OMIM: 620879

Enables fibroblast growth factor binding activity and heparin binding activity. Acts upstream of or within positive regulation of fibroblast growth factor receptor signaling pathway and positive regulation of vascular permeability. Located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
2
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.89
LOEUF
—
Mechanism

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.89LOEUF
pLI 0.001
Z-score -0.34
OE 1.20 (0.55–1.89)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.66Z-score
OE missense 1.19 (1.02–1.38)
119 obs / 100.3 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.20 (0.55–1.89)
0≤0.351.4
Missense OE?1.19 (1.02–1.38)
0≤0.61.4
Synonymous OE?1.08
0≤1.21.6
LoF obs/exp: 4 / 3.3Missense obs/exp: 119 / 100.3Syn Z: -0.42

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

FGFBP3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients