FGF2

Chr 4

fibroblast growth factor 2

Also known as: BFGF, FGF-2, FGFB, HBGF-2

NCBI Gene: 2247ENSG00000138685UniProt: P09038

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]

GeneReviewsResearchGenerating clinical summary…
6
Active trials
448
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.04
LOEUF
Multiple*
Mechanism· predicted
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GeneReview available — FGF2
Authoritative clinical overview · Recommended first read
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Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.04LOEUF
pLI 0.018
Z-score 1.49
OE 0.46 (0.22–1.04)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.94Z-score
OE missense 0.76 (0.65–0.91)
95 obs / 124.4 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.46 (0.22–1.04)
0≤0.351.4
Missense OE?0.76 (0.65–0.91)
0≤0.61.4
Synonymous OE?1.01
0≤1.21.6
LoF obs/exp: 4 / 8.8Missense obs/exp: 95 / 124.4Syn Z: -0.04

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

FGF2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov
Porphyria, Acute Intermittent

Clinical Research on Acute Intermittent Porphyria and the Use of Carbohydrate-Rich Diet as a Treatment

RECRUITING
NCT06273644Phase NANordlandssykehuset HFStarted 2024-01-27
Carbohydrates
Preeclampsia (PE)Intrauterine Growth Restriction (IUGR)Placental Insufficiency

Statin Intervention for Severe Early-Onset Placental Insufficiency. (STATIN-PRE Trial)

RECRUITING
NCT07098975Phase PHASE2Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant PauStarted 2026-01-14
Pravastatin 40 mgPlacebo
Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2AFibroblast Growth Factor Basic Form MeasurementFLT3 Internal Tandem Duplication

Nintedanib and Azacitidine in Treating Participants With HOX Gene Overexpression Relapsed or Refractory Acute Myeloid Leukemia

ACTIVE NOT RECRUITING
NCT03513484Phase PHASE1Northwestern UniversityStarted 2018-11-14
AzacitidineLaboratory Biomarker AnalysisNintedanib
Healthy AdultsHigh AltitudeIsolation, Social

Human Milk Oligosaccharides (HMOs) and Gut Microbiota, Immune System in Antarctica

ENROLLING BY INVITATION
NCT06133530Phase NAIU University of Applied SciencesStarted 2023-09-24
Human milk oligosaccharidesMaltose
Diabete Type 2Cardio Vascular Disease

Role of Endothelial Progenitor Cells Dysregulation and Inflammation in the Pathophysiology of Cardiovascular Complications of Type 2 Diabetes

RECRUITING
NCT07556497Weill Cornell Medical College in QatarStarted 2020-11-17
HR+/HER2-negative Breast CancerMetastatic Breast Cancer

Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast Cancer

RECRUITING
NCT05455619Phase PHASE1, PHASE2SynDevRx, Inc.Started 2022-08-26
Evexomostat

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients