FER1L5
Chr 2fer-1 like family member 5
Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of neurotransmitter secretion. Predicted to be located in plasma membrane. Predicted to be active in synaptic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
354 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 22 | 0 | 22 |
Likely Pathogenic | 0 | 0 | 10 | 0 | 10 |
VUS | 0 | 196 | 95 | 0 | 291 |
Likely Benign | 0 | 20 | 9 | 0 | 29 |
Benign | 0 | 1 | 0 | 1 | 2 |
| Total | 0 | 217 | 136 | 1 | 354 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
FER1L5 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools