FENDRR

Chr 16

FOXF1 adjacent non-coding developmental regulatory RNA

Also known as: FOXF1-AS1, FOXF1AS1, TCONS_00024240, lincFOXF1, onco-lncRNA-21

NCBI Gene: 400550ENSG00000268388

This gene encodes a long non-coding RNA that binds to polycomb repressive complex 2 (PRC2) and TrxG/MLL complexes to methylate target gene promoters and reduce their expression, and is essential for normal heart and body wall development. Mutations cause abnormal development affecting cardiac and body wall structures. The inheritance pattern and specific disease mechanisms in humans have not been established.

Summary from RefSeq
0
Active trials
18
Pubs (1 yr)
0
P/LP submissions
—
P/LP missense
—
LOEUF
—
Mechanism
Clinical Summary— FENDRR

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

FENDRR · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
Open Research Assistant →
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
PubTator3
Top 5 full-text resultsSearch PubTator3 ↗
Key Publications
Landmark & review papers · by relevance
PubMed
Top 5 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients