FDCSP

Chr 4

follicular dendritic cell secreted protein

Also known as: C4orf7, FDC-SP

NCBI Gene: 260436ENSG00000181617UniProt: Q8NFU4

This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion. [provided by RefSeq, Dec 2011]

ResearchGenerating clinical summary…
0
Active trials
14
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.40
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.40LOEUF
pLI 0.082
Z-score 1.05
OE 0.46 (0.18–1.40)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.09Z-score
OE missense 1.04 (0.82–1.32)
48 obs / 46.3 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.46 (0.18–1.40)
0≤0.351.4
Missense OE?1.04 (0.82–1.32)
0≤0.61.4
Synonymous OE?0.96
0≤1.21.6
LoF obs/exp: 2 / 4.4Missense obs/exp: 48 / 46.3Syn Z: 0.12

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

FDCSP · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients