FCRLB

Chr 1

Fc receptor like B

Also known as: FCRL2, FCRLM2, FCRLY, FREB-2, FREB2, FcRY

NCBI Gene: 127943ENSG00000162746UniProt: Q6BAA4OMIM: 609251

FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions (Chikaev et al., 2005 [PubMed 15676285]).[supplied by OMIM, Mar 2008]

OMIMResearchGenerating clinical summary…
0
Active trials
2
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.50
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.50LOEUF
pLI 0.000
Z-score 0.09
OE 0.97 (0.65–1.50)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.52Z-score
OE missense 0.91 (0.81–1.01)
217 obs / 239.7 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.97 (0.65–1.50)
0≤0.351.4
Missense OE?0.91 (0.81–1.01)
0≤0.61.4
Synonymous OE?1.01
0≤1.21.6
LoF obs/exp: 15 / 15.4Missense obs/exp: 217 / 239.7Syn Z: -0.10

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

FCRLB · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients