FCRL5

Chr 1

Fc receptor like 5

Also known as: BXMAS1, CD307, CD307e, FCRH5, IRTA2, PRO820

This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]

OMIMResearchGenerating clinical summary…
0
Active trials
18
Pubs (1 yr)
P/LP submissions
P/LP missense
1.06
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.06LOEUF
pLI 0.000
Z-score 1.24
OE 0.78 (0.581.06)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.61Z-score
OE missense 0.93 (0.861.00)
486 obs / 525.4 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.78 (0.581.06)
00.351.4
Missense OE?0.93 (0.861.00)
00.61.4
Synonymous OE?1.00
01.21.6
LoF obs/exp: 30 / 38.3Missense obs/exp: 486 / 525.4Syn Z: -0.01

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

FCRL5 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →