FCGR2B

Chr 1

Fc gamma receptor IIb

Also known as: CD32, CD32B, FCG2, FCGR2, IGFR2

NCBI Gene: 2213ENSG00000072694UniProt: P31994

The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

ResearchGenerating clinical summary…

Primary Disease Associations & Inheritance

UniProtSystemic lupus erythematosus

Clinical highlights

Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
0
Active trials
54
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.63
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.63LOEUF
pLI 0.456
Z-score 2.33
OE 0.20 (0.08–0.63)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
0.11Z-score
OE missense 0.97 (0.84–1.13)
131 obs / 134.5 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.20 (0.08–0.63)
0≤0.351.4
Missense OE?0.97 (0.84–1.13)
0≤0.61.4
Synonymous OE?1.17
0≤1.21.6
LoF obs/exp: 2 / 9.9Missense obs/exp: 131 / 134.5Syn Z: -0.94

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

FCGR2B · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients