FCGR1A

Chr 1

Fc gamma receptor Ia

Also known as: CD64, CD64A, FCG1, FCGR1, FCRI, FcgammaRI, IGFR1

This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…
3
Active trials
48
Pubs (1 yr)
P/LP submissions
P/LP missense
1.08
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.08LOEUF
pLI 0.000
Z-score 1.35
OE 0.60 (0.351.08)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.58Z-score
OE missense 0.88 (0.771.00)
150 obs / 171.3 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.60 (0.351.08)
00.351.4
Missense OE?0.88 (0.771.00)
00.61.4
Synonymous OE?0.94
01.21.6
LoF obs/exp: 8 / 13.3Missense obs/exp: 150 / 171.3Syn Z: 0.37

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

FCGR1A · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.