FCER1G

Chr 1

Fc epsilon receptor Ig

Also known as: FCRG

NCBI Gene: 2207ENSG00000158869UniProt: P30273

The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
0
Active trials
64
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.61
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Moderate LoF intolerance
LoF Constraint?
0.61LOEUF
pLI 0.663
Z-score 2.26
OE 0.13 (0.04–0.61)
Moderately constrained

Typical tolerance to LoF variation

Missense Constraint?
-0.02Z-score
OE missense 1.01 (0.79–1.29)
45 obs / 44.6 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.13 (0.04–0.61)
0≤0.351.4
Missense OE?1.01 (0.79–1.29)
0≤0.61.4
Synonymous OE?0.85
0≤1.21.6
LoF obs/exp: 1 / 7.8Missense obs/exp: 45 / 44.6Syn Z: 0.51

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

FCER1G · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients