FBXW10B
Chr 17F-box and WD repeat domain containing 10B
Also known as: C170RF1, C17ORF1, C17ORF1A, CDRT1, FBXW10P1, HREP, SM25H2
FBXW10B encodes an F-box protein that functions as part of SCF ubiquitin ligase complexes to target specific proteins for degradation. The gene is not constrained against loss-of-function variants and no definitive disease associations have been established in the provided data. Clinical significance of variants in this gene requires careful evaluation given the lack of established phenotypes.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
70 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 49 | 0 | 49 |
Likely Pathogenic | 0 | 0 | 1 | 0 | 1 |
VUS | 0 | 5 | 2 | 0 | 7 |
Likely Benign | 0 | 1 | 1 | 0 | 2 |
Benign | 0 | 1 | 1 | 0 | 2 |
| Total | 0 | 7 | 54 | 0 | 61 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
FBXW10B · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools