FBXO25
Chr 8F-box protein 25
Also known as: FBX25
The protein functions as a substrate-recognition component of SCF-type E3 ubiquitin ligase complexes, which target specific proteins for degradation through the ubiquitin-proteasome system. This gene is extremely intolerant to loss-of-function variants (pLI near 1.0), indicating that haploinsufficiency is likely pathogenic, though specific disease associations have not yet been established in humans. The inheritance pattern for pathogenic variants would be expected to be autosomal dominant given the high constraint against loss-of-function.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
FBXO25 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools