FBXO15
Chr 18F-box protein 15
Also known as: FBX15
The protein functions as a substrate-recognition component of SCF ubiquitin ligase complexes, which target specific proteins for degradation. The gene is highly constrained against loss-of-function variants (LOEUF 0.42), but no specific human diseases have been definitively associated with FBXO15 mutations in the medical literature to date. Further research is needed to establish any clinical phenotypes and inheritance patterns associated with this gene.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
ClinVar Variant Classifications
250 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 144 | 0 | 144 |
Likely Pathogenic | 0 | 0 | 6 | 0 | 6 |
VUS | 0 | 73 | 14 | 0 | 87 |
Likely Benign | 0 | 5 | 0 | 1 | 6 |
Benign | 0 | 0 | 0 | 1 | 1 |
| Total | 0 | 78 | 164 | 2 | 244 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
FBXO15 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools