FBXL18
Chr 7F-box and leucine rich repeat protein 18
Also known as: Fbl18
FBXL18 encodes a substrate-recognition component of SCF-type E3 ubiquitin ligase complexes that targets proteins like FBXL7 for polyubiquitylation and proteasomal degradation. The gene shows very low constraint to loss-of-function variants (pLI <0.01, LOEUF 0.88), but no established human disease associations have been reported to date. Clinical significance of FBXL18 variants remains uncertain pending additional evidence.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
FBXL18 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools