FAM86B2-DT

Chr 8

FAM86B2 divergent transcript

NCBI Gene: 100506990

I cannot provide a clinical summary for FAM86B2-DT as no information about this gene's protein function, associated diseases, inheritance patterns, or mechanisms of pathogenicity has been provided in the data you've given me.

Research Assistant →
0
Active trials
0
Pubs (1 yr)
32
P/LP submissions
—
P/LP missense
—
LOEUF
—
Mechanism
Clinical Summary— FAM86B2-DT
📋
ClinVar Variants
32 unique Pathogenic / Likely Pathogenic· 1 VUS of 46 total submissions
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Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/FAM86B2-DT?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

46 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic32
VUS1
Benign5
32
Pathogenic
1
VUS
5
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————32
Likely Pathogenic
————0
VUS
————1
Likely Benign
————0
Benign
————5
Total—38

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

FAM86B2-DT · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

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External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients