FAM86B2

Chr 8

family with sequence similarity 86 member B2

Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in methylation. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
P/LP submissions
P/LP missense
1.74
LOEUF
Mechanism
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.74LOEUF
pLI 0.000
Z-score -0.05
OE 1.02 (0.591.74)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-2.39Z-score
OE missense 1.67 (1.471.88)
169 obs / 101.4 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.02 (0.591.74)
00.351.4
Missense OE?1.67 (1.471.88)
00.61.4
Synonymous OE?1.42
01.21.6
LoF obs/exp: 8 / 7.8Missense obs/exp: 169 / 101.4Syn Z: -2.15

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

FAM86B2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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