FAM3A

Chr X

FAM3 metabolism regulating signaling molecule A

Also known as: 2.19, DLD, DXS560S, XAP-7

This gene encodes a cytokine-like protein that may function as a defensin against fungal pathogens and is involved in glucose and lipid metabolism regulation. The gene shows moderate constraint against loss-of-function variants (LOEUF 0.602), but no established Mendelian diseases have been definitively associated with FAM3A mutations in current medical literature. Clinical significance of variants in this gene remains uncertain pending further research.

OMIMResearchSummary from RefSeq, UniProt
LOEUF 0.60
Clinical SummaryFAM3A
Population Constraint (gnomAD)
Moderately constrained gene (pLI 0.67) — some intolerance to loss-of-function variants.

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Moderate LoF intolerance
LoF Constraint
0.60LOEUF
pLI 0.669
Z-score 2.27
OE 0.13 (0.040.60)
Moderately constrained

Typical tolerance to LoF variation

Missense Constraint
0.93Z-score
OE missense 0.75 (0.620.90)
79 obs / 105.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios
LoF OE0.13 (0.040.60)
00.351.4
Missense OE0.75 (0.620.90)
00.61.4
Synonymous OE1.16
01.21.6
LoF obs/exp: 1 / 7.9Missense obs/exp: 79 / 105.8Syn Z: -0.85

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

FAM3A · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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