FAM24A

Chr 10

family with sequence similarity 24 member A

NCBI Gene: 118670ENSG00000203795UniProt: A6NFZ4

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.93
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.93LOEUF
pLI 0.015
Z-score -0.69
OE 1.69 (0.49–1.93)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.24Z-score
OE missense 0.91 (0.73–1.14)
55 obs / 60.3 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.69 (0.49–1.93)
0≤0.351.4
Missense OE?0.91 (0.73–1.14)
0≤0.61.4
Synonymous OE?0.97
0≤1.21.6
LoF obs/exp: 2 / 1.2Missense obs/exp: 55 / 60.3Syn Z: 0.11

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

FAM24A · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients