FAM224B
Chr Yfamily with sequence similarity 224 member B
Also known as: LINC00230B, NCRNA00230B
This locus is transcribed but does not appear to encode a protein and consists of two identical copies located in a palindromic region on chromosome Y. No disease associations have been established for FAM224B mutations. Given its location on the Y chromosome, any potential effects would follow paternal inheritance patterns.
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
35 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | — | — | — | — | 25 |
Likely Pathogenic | — | — | — | — | 2 |
VUS | — | — | — | — | 4 |
Likely Benign | — | — | — | — | 3 |
Benign | — | — | — | — | 0 |
Conflicting | — | 1 | |||
| Total | — | 35 | |||
Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
FAM224B · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools