FAM199X

Chr X

family with sequence similarity 199, X-linked

Also known as: CXorf39

I don't have sufficient information about the FAM199X gene to write a clinical summary. The gene name suggests it's located on the X chromosome, but I would need specific data about the protein function, associated diseases, and clinical phenotypes to provide an accurate summary according to your guidelines.

0
Active trials
0
Pubs (1 yr)
0
P/LP submissions
P/LP missense
0.56
LOEUF
Mechanism
Clinical SummaryFAM199X
Population Constraint (gnomAD)
Moderately constrained gene (pLI 0.57) — some intolerance to loss-of-function variants.

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Moderate LoF intolerance
LoF Constraint
0.56LOEUF
pLI 0.573
Z-score 2.54
OE 0.18 (0.070.56)
Moderately constrained

More LoF-intolerant than ~75% of genes

Missense Constraint
2.50Z-score
OE missense 0.42 (0.340.52)
63 obs / 148.8 exp
Mild constraint

Moderately missense-constrained (top ~2.5%)

Observed / Expected Ratios
LoF OE0.18 (0.070.56)
00.351.4
Missense OE0.42 (0.340.52)
00.61.4
Synonymous OE0.83
01.21.6
LoF obs/exp: 2 / 11.2Missense obs/exp: 63 / 148.8Syn Z: 0.99

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

FAM199X · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →
Clinical Literature
Open Research Assistant →