FAM163A

Chr 1

family with sequence similarity 163 member A

Also known as: C1orf76, NDSP

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
3
Pubs (1 yr)
P/LP submissions
P/LP missense
1.19
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.19LOEUF
pLI 0.115
Z-score 1.31
OE 0.38 (0.151.19)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.66Z-score
OE missense 0.82 (0.690.98)
87 obs / 106.0 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.38 (0.151.19)
00.351.4
Missense OE?0.82 (0.690.98)
00.61.4
Synonymous OE?1.07
01.21.6
LoF obs/exp: 2 / 5.2Missense obs/exp: 87 / 106.0Syn Z: -0.40

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

FAM163A · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →