FAM114A2

Chr 5

family with sequence similarity 114 member A2

Also known as: 133K02, C5orf3

The protein is predicted to bind purine nucleotides, but no specific diseases have been definitively associated with FAM114A2 mutations in the provided data. The gene shows tolerance to loss-of-function variants based on constraint metrics, suggesting haploinsufficiency may not cause disease.

Summary from RefSeq
Research Assistant →
0
Active trials
1
Pubs (1 yr)
0
P/LP submissions
P/LP missense
1.04
LOEUF
Mechanism
Clinical SummaryFAM114A2
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
Some data sources returned errors (1)

ensembl: TimeoutError: The operation was aborted due to timeout

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint
1.04LOEUF
pLI 0.000
Z-score 1.40
OE 0.70 (0.481.04)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint
-0.38Z-score
OE missense 1.07 (0.961.18)
270 obs / 253.0 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios
LoF OE0.70 (0.481.04)
00.351.4
Missense OE1.07 (0.961.18)
00.61.4
Synonymous OE1.16
01.21.6
LoF obs/exp: 18 / 25.7Missense obs/exp: 270 / 253.0Syn Z: -1.27

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

FAM114A2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Key Publications
Landmark & review papers · by relevance
PubMed
Top 1 results · since 2015Search PubMed ↗