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ETL2

Chr 12AD

epilepsy, familial temporal lobe

Also known as: FTLE

ETL2 encodes a protein involved in neuronal function and synaptic transmission. Mutations cause familial temporal lobe epilepsy type 2, which typically presents as focal seizures originating from the temporal lobe. The condition follows an autosomal dominant inheritance pattern.

OMIMResearchSummary from OMIM
AD1 OMIM phenotype
Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/ETL2?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

ETL2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC