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EIG17

Chr 19AD

hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2

Also known as: BCNG-2, BCNG2, EIG17, FEB2, GEFSP11, HAC-1

NCBI Gene: 610 OMIM: 602477

The protein is a hyperpolarization-activated cation channel that generates pacemaker activity in the heart and brain and is activated by cAMP to produce fast, large currents. Mutations cause generalized epilepsy with febrile seizures plus type 11 and familial febrile seizures, with inheritance following an autosomal dominant pattern. The epilepsy phenotypes typically involve febrile seizures that may progress to other generalized seizure types.

OMIM ResearchSummary from RefSeq, OMIM

The protein encoded by this gene is a hyperpolarization-activated cation channel involved in the generation of native pacemaker activity in the heart and in the brain. The encoded protein is activated by cAMP and can produce a fast, large current. Defects in this gene were noted as a possible cause of some forms of epilepsy. [provided by RefSeq, Jan 2017]

OMIM ResearchGenerating clinical summary…