EIF3M

Chr 11

eukaryotic translation initiation factor 3 subunit M

Also known as: B5, GA17, PCID1, TANGO7, hfl-B5

The protein is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is essential for multiple steps in protein synthesis initiation, including ribosome assembly, mRNA recruitment, and translation of specific mRNAs involved in cell proliferation and apoptosis. Mutations cause neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy, which follows autosomal recessive inheritance. The gene shows moderate constraint against loss-of-function variants (LOEUF 0.607), consistent with early-onset developmental abnormalities when both copies are disrupted.

Summary from RefSeq, UniProt
Research Assistant →
0
Active trials
5
Pubs (1 yr)
0
P/LP submissions
P/LP missense
0.61
LOEUF
DN
Mechanism· predicted
Clinical SummaryEIF3M
Population Constraint (gnomAD)
Constrained for loss-of-function variants (OE-LoF 0.32) despite low pLI — interpret in context.

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint
0.61LOEUF
pLI 0.017
Z-score 2.92
OE 0.32 (0.180.61)
Tolerant

Typical tolerance to LoF variation

Missense Constraint
0.97Z-score
OE missense 0.80 (0.710.92)
156 obs / 193.9 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios
LoF OE0.32 (0.180.61)
00.351.4
Missense OE0.80 (0.710.92)
00.61.4
Synonymous OE0.82
01.21.6
LoF obs/exp: 7 / 21.6Missense obs/exp: 156 / 193.9Syn Z: 1.16
DN
0.6743th %ile
GOF
0.5660th %ile
LOF
0.2968th %ile

The highest-scoring mechanism for this gene is dominant-negative.

DNprediction above median

Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.

Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

EIF3M · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Key Publications
Landmark & review papers · by relevance
PubMed
Top 1 results · since 2015Search PubMed ↗