EIF3CL

Chr 16

eukaryotic translation initiation factor 3 subunit C like

The protein encoded by this gene is a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex. The encoded protein is nearly identical to another protein, eIF3c, from a related gene. The eIF3 complex binds the 40S ribosome and mRNAs to enable translation initiation. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

ResearchGenerating clinical summary…
0
Active trials
2
Pubs (1 yr)
P/LP submissions
P/LP missense
1.70
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.70LOEUF
pLI 0.012
Z-score 0.49
OE 0.74 (0.331.70)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.91Z-score
OE missense 0.58 (0.410.83)
21 obs / 36.4 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.74 (0.331.70)
00.351.4
Missense OE?0.58 (0.410.83)
00.61.4
Synonymous OE?0.58
01.21.6
LoF obs/exp: 3 / 4.1Missense obs/exp: 21 / 36.4Syn Z: 1.23

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

EIF3CL · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →