EIF3C

Chr 16

eukaryotic translation initiation factor 3 subunit C

Also known as: EIF3S8, eIF3-p110

Enables ribosome binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of translation and translational initiation. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
13
Pubs (1 yr)
P/LP submissions
P/LP missense
1.93
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.93LOEUF
pLI 0.000
Z-score -0.84
OE 1.45 (0.731.93)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.07Z-score
OE missense 0.97 (0.771.25)
45 obs / 46.2 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.45 (0.731.93)
00.351.4
Missense OE?0.97 (0.771.25)
00.61.4
Synonymous OE?0.64
01.21.6
LoF obs/exp: 6 / 4.1Missense obs/exp: 45 / 46.2Syn Z: 1.19

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

EIF3C · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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