EFNA4-EFNA3
Chr 1EFNA4-EFNA3 readthrough
This locus represents naturally occurring readthrough transcription between the neighboring EFNA4 (ephrin A4) and EFNA3 (ephrin A3) genes on chromosome 1. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jun 2022]
Some data sources returned errors (2)
gnomad: Error: Gene not found
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
91 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 0 | 0 | 0 |
Likely Pathogenic | 0 | 0 | 0 | 0 | 0 |
VUS | 1 | 61 | 0 | 0 | 62 |
Likely Benign | 0 | 5 | 5 | 7 | 17 |
Benign | 0 | 0 | 1 | 1 | 2 |
| Total | 1 | 66 | 6 | 8 | 81 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →4 pathogenic / likely-pathogenic (of 5) ClinVar copy-number / structural variants overlap EFNA4-EFNA3 — these span large chromosomal regions, not the gene specifically, and are excluded from the counts above. Explore in CNV tools →
Protein Context — Lollipop Plot
EFNA4-EFNA3 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools