EEF1AKMT2
Chr 10EEF1A lysine methyltransferase 2
Also known as: C10orf138, Efm4, METTL10
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.25LOEUF
pLI 0.000
Z-score 0.83
OE 0.77 (0.49–1.25)
Highly tolerant — LoF variants common in population
Missense Constraint?
0.25Z-score
OE missense 0.94 (0.81–1.09)
128 obs / 136.3 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.77 (0.49–1.25)
0≤0.351.4
Missense OE?0.94 (0.81–1.09)
0≤0.61.4
Synonymous OE?0.94
0≤1.21.6
LoF obs/exp: 12 / 15.5Missense obs/exp: 128 / 136.3Syn Z: 0.33
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
EEF1AKMT2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools