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EBS5B

Chr 8

plectin

Also known as: EBS1, EBS5A, EBS5B, EBS5C, EBS5D, EBSMD, EBSND, EBSO

Plectin is a large cytoskeletal protein that interlinks different elements of the cytoskeleton and serves as a scaffolding platform for signaling complexes, playing crucial roles in maintaining cell and tissue integrity. Mutations cause epidermolysis bullosa simplex with muscular dystrophy, characterized by skin fragility with blistering and progressive muscle weakness. This condition follows autosomal recessive inheritance.

GeneReviewsResearchSummary from RefSeq, OMIM
📖
GeneReview available — EBS5B
Authoritative clinical overview · Recommended first read
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Some data sources returned errors (3)

ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/EBS5B?content-type=application/json&expand=1

gnomad: Error: Gene not found

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

EBS5B · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
PubTator3
Top 2 full-text resultsSearch PubTator3 ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found