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EA1

Chr 12

CD69 molecule

Also known as: AIM, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3

This gene encodes a calcium-dependent lectin that functions as a type II transmembrane receptor involved in T lymphocyte activation and signal transmission in natural killer cells and platelets. Mutations cause episodic ataxia/myokymia syndrome, characterized by intermittent episodes of ataxia and continuous muscle fiber activity. The condition follows autosomal dominant inheritance.

GeneReviewsResearchSummary from RefSeq, OMIM
Clinical SummaryEA1
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Clinical Trials
1 active or recruiting trial — potential therapeutic options may be available
📖
GeneReview available — EA1
Authoritative clinical overview · Recommended first read
Open GeneReview ↗
Some data sources returned errors (3)

ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/EA1?content-type=application/json&expand=1

gnomad: Error: Gene not found

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

EA1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold
Clinical Literature
Open Research Assistant →
Key Publications
Landmark & review papers · by relevance
PubMed
Top 5 results · since 2015Search PubMed ↗