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DYT3
Chr XXLRdystonia 3 (with Parkinsonism)
Also known as: XDP
The DYT3 gene encodes TAF1, a component of the TFIID transcription factor complex that regulates RNA polymerase II-mediated gene transcription. Mutations cause X-linked dystonia-parkinsonism (also known as Lubag disease), a progressive movement disorder typically beginning in adulthood with dystonia that may later develop parkinsonian features. The condition follows X-linked recessive inheritance, primarily affecting males.
Some data sources returned errors (2)
ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/DYT3?content-type=application/json&expand=1
gnomad: Error: Gene not found
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
DYT3 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
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Links to major genomics databases and tools