DYNLT5

Chr 1

dynein light chain Tctex-type family member 5

Also known as: TCTEX1D1

NCBI Gene: 200132 ENSG00000152760 UniProt: Q8N7M0 OMIM: 619994

The protein is predicted to bind dynein intermediate chains and participate in microtubule-based transport as part of the cytoplasmic dynein complex. This gene is extremely intolerant to loss-of-function variants (pLI near 1.0), suggesting mutations would likely cause severe disease, but no specific genetic disorders have been definitively associated with DYNLT5 mutations to date. Any potential inheritance pattern remains to be established through future clinical cases.

OMIM ResearchSummary from RefSeq

Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

1.57

LOEUF

Mechanism· predicted