DYNLT2

Chr 6

dynein light chain Tctex-type 2

Also known as: TCTE3, TCTEX1D3, TCTEX2, Tctex4, oda12

NCBI Gene: 6991ENSG00000184786UniProt: Q8IZS6

Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be located in cytosol and sperm flagellum. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
1
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.83
LOEUF
GOF
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.83LOEUF
pLI 0.000
Z-score -0.65
OE 1.22 (0.78–1.83)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.04Z-score
OE missense 1.01 (0.86–1.19)
106 obs / 104.7 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.22 (0.78–1.83)
0≤0.351.4
Missense OE?1.01 (0.86–1.19)
0≤0.61.4
Synonymous OE?0.82
0≤1.21.6
LoF obs/exp: 12 / 9.8Missense obs/exp: 106 / 104.7Syn Z: 0.89

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

DYNLT2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients