DUSP29

Chr 10

dual specificity phosphatase 29

Also known as: DUPD1, DUSP27, FMDSP

NCBI Gene: 338599ENSG00000188716UniProt: Q68J44OMIM: 618574

Enables protein homodimerization activity and protein tyrosine/serine/threonine phosphatase activity. Involved in protein dephosphorylation. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
—
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.88
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.88LOEUF
pLI 0.000
Z-score -0.69
OE 1.28 (0.75–1.88)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.59Z-score
OE missense 0.87 (0.75–1.00)
133 obs / 153.7 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.28 (0.75–1.88)
0≤0.351.4
Missense OE?0.87 (0.75–1.00)
0≤0.61.4
Synonymous OE?0.86
0≤1.21.6
LoF obs/exp: 9 / 7.0Missense obs/exp: 133 / 153.7Syn Z: 0.92

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

DUSP29 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients