DUSP23

Chr 1

dual specificity phosphatase 23

Also known as: DUSP25, LDP-3, LDP3, MOSP, VHZ

NCBI Gene: 54935ENSG00000158716UniProt: Q9BVJ7

Enables protein tyrosine/serine/threonine phosphatase activity. Involved in dephosphorylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
6
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.69
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.69LOEUF
pLI 0.001
Z-score 0.30
OE 0.86 (0.45–1.69)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.30Z-score
OE missense 0.91 (0.76–1.10)
78 obs / 85.7 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.86 (0.45–1.69)
0≤0.351.4
Missense OE?0.91 (0.76–1.10)
0≤0.61.4
Synonymous OE?1.18
0≤1.21.6
LoF obs/exp: 5 / 5.8Missense obs/exp: 78 / 85.7Syn Z: -0.87

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

DUSP23 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients