DRG1
Chr 22ARdevelopmentally regulated GTP binding protein 1
Also known as: NEDD3, TANALS
DRG1 encodes a stress-responsive protein that regulates microtubule dynamics, maintains mitotic spindle integrity, and is essential for peripheral nerve myelin sheath development and maintenance. Biallelic mutations cause Tan-Almurshedi syndrome, an autosomal recessive disorder affecting the nervous system. The gene shows moderate constraint against loss-of-function variants (LOEUF 0.53), reflecting its importance in cellular function.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Moderately missense-constrained (top ~2.5%)
Predictions shown for reference only — model trained on dominant genes, not applicable to AR conditions.
The Badonyi & Marsh prediction model was trained exclusively on dominant disease genes. Predictions are not reliable for genes with autosomal recessive inheritance and are shown at reduced opacity for reference only.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
DRG1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools