DPYSL3

Chr 5

dihydropyrimidinase like 3

Also known as: CRMP-4, CRMP4, DRP-3, DRP3, LCRMP, ULIP, ULIP-1

NCBI Gene: 1809 ENSG00000113657 UniProt: Q14195 OMIM: 601168

DPYSL3 encodes a protein necessary for semaphorin signaling and cytoskeletal remodeling that plays a role in axon guidance, neuronal growth cone collapse, and cell migration. Mutations cause neurodevelopmental disorders with autosomal dominant inheritance. This gene is highly constrained against loss-of-function variants, indicating that such mutations are likely to cause severe developmental phenotypes.

OMIM ResearchSummary from RefSeq, UniProt

Enables filamin binding activity. Predicted to be involved in several processes, including actin filament organization; regulation of plasma membrane bounded cell projection organization; and response to axon injury. Predicted to act upstream of or within nervous system development. Predicted to be located in several cellular components, including exocytic vesicle; lamellipodium; and obsolete extracellular space. Predicted to be part of filamentous actin. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jun 2026]

OMIM ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

0.22

LOEUF· LoF intol.

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Mechanism