DNM3OS

Chr 1

DNM3 opposite strand/antisense RNA

Also known as: DNM3-AS1, MIR199A2HG

NCBI Gene: 100628315 ENSG00000230630 OMIM: 610721

This gene encodes a long non-coding RNA that functions as a microRNA inhibitor through base-pairing interactions and is predicted to be part of the RISC complex involved in regulating macromolecule metabolism. No established disease associations have been reported for mutations in this gene based on the provided information.

OMIM ResearchSummary from RefSeq

Enables miRNA inhibitor activity via base-pairing. Involved in cellular response to transforming growth factor beta stimulus; positive regulation of miRNA catabolic process; and regulation of gene expression. Predicted to be part of RISC complex. [provided by Alliance of Genome Resources, Jun 2026]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

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LOEUF

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Mechanism

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

Background carrier burden — how many people carry a rare variant somewhere in DNM3OS?

gnomAD v4 · ~189k individuals · PASS only

Rare means allele frequency under

Rare missense

none observed

0 rare PASS variants

Rare truncating (LoF)

1 in 20,000

5 rare PASS variants

Rare synonymous (reference)

none observed

0 rare PASS variants

Rare missense and truncating variants are carried at similar rates in DNM3OS; this gene does not show strong loss-of-function constraint by this measure. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 5 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~95k	none seen	1 in 14,000
African / African American	~21k	none seen	≈ 1 in 5,200
East Asian	~6,497	none seen	≈ 1 in 6,100
Ashkenazi Jewish	~5,786	none seen	≈ 1 in 2,900
Middle Eastern	~1,415	none seen	≈ 1 in 620

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.