DNAJC9

Chr 10

DnaJ heat shock protein family (Hsp40) member C9

Also known as: HDJC9, JDD1, SB73

Enables heat shock protein binding activity; histone binding activity; and protein-folding chaperone binding activity. Involved in nucleosome assembly and positive regulation of ATP-dependent activity. Located in several cellular components, including cytosol; nucleoplasm; and obsolete extracellular space. Part of protein folding chaperone complex. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…
0
Active trials
7
Pubs (1 yr)
P/LP submissions
P/LP missense
0.87
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
0.87LOEUF
pLI 0.005
Z-score 1.92
OE 0.44 (0.240.87)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
0.12Z-score
OE missense 0.97 (0.841.12)
135 obs / 139.0 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.44 (0.240.87)
00.351.4
Missense OE?0.97 (0.841.12)
00.61.4
Synonymous OE?0.78
01.21.6
LoF obs/exp: 6 / 13.7Missense obs/exp: 135 / 139.0Syn Z: 1.28

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

DNAJC9 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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