DNAJC2

The protein functions as a molecular chaperone that assists nascent polypeptide folding at ribosomes in the cytosol and regulates chromatin by displacing polycomb repressor complexes in the nucleus. Mutations cause spastic paraplegia with intellectual disability through autosomal recessive inheritance. This gene is highly constrained against loss-of-function variants, indicating that complete loss of protein function is likely incompatible with normal development.