DNAJA2
Chr 16DnaJ heat shock protein family (Hsp40) member A2
Also known as: CPR3, DJ3, DJA2, DNAJ, DNJ3, HIRIP4, PRO3015, RDJ2
The protein functions as a co-chaperone that stimulates Hsc70 ATPase activity and assists in protein folding and mitochondrial protein import. Mutations cause spastic paraplegia-59, an autosomal recessive disorder characterized by progressive spasticity primarily affecting the lower limbs. This gene is highly constrained against loss-of-function variants (pLI = 1.00, LOEUF = 0.21), indicating that protein function is critical for normal development.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Moderately missense-constrained (top ~2.5%)
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
DNAJA2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools