DNAI4

Chr 1

dynein axonemal intermediate chain 4

Also known as: DIC4, WDR78

NCBI Gene: 79819ENSG00000152763UniProt: Q5VTH9OMIM: 619156

Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in axonemal dynein complex assembly and cilium movement. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in axoneme; dynein axonemal particle; and motile cilium. Predicted to be part of axonemal dynein complex. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
3
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.93
LOEUF
DN
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.93LOEUF
pLI 0.000
Z-score 1.92
OE 0.70 (0.53–0.93)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
-0.06Z-score
OE missense 1.01 (0.93–1.09)
438 obs / 434.4 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.70 (0.53–0.93)
0≤0.351.4
Missense OE?1.01 (0.93–1.09)
0≤0.61.4
Synonymous OE?1.05
0≤1.21.6
LoF obs/exp: 33 / 47.3Missense obs/exp: 438 / 434.4Syn Z: -0.47

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

DNAI4 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients