DNAI3
Chr 1dynein axonemal intermediate chain 3
Also known as: DIC3, NYD-SP29, WDR63
DNAI3 encodes a protein that negatively regulates cell migration through inhibition of Arp2/3 complex-mediated actin polymerization and is potentially involved in ciliary function through association with axonemal dynein complexes. Mutations cause primary ciliary dyskinesia with autosomal recessive inheritance. The gene shows tolerance to loss-of-function variants, consistent with the recessive inheritance pattern of associated ciliopathy.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
DNAI3 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools