DNAI3

Chr 1

dynein axonemal intermediate chain 3

Also known as: DIC3, NYD-SP29, WDR63

NCBI Gene: 126820ENSG00000162643UniProt: Q8IWG1

Enables Arp2/3 complex binding activity. Involved in negative regulation of Arp2/3 complex-mediated actin nucleation and negative regulation of cell migration. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
3
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.76
LOEUF
—
Mechanism
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.76LOEUF
pLI 0.000
Z-score 2.98
OE 0.56 (0.41–0.76)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
1.02Z-score
OE missense 0.87 (0.80–0.94)
410 obs / 472.3 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.56 (0.41–0.76)
0≤0.351.4
Missense OE?0.87 (0.80–0.94)
0≤0.61.4
Synonymous OE?0.97
0≤1.21.6
LoF obs/exp: 29 / 52.2Missense obs/exp: 410 / 472.3Syn Z: 0.34

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

DNAI3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients