DMRTA1

Chr 9

DMRT like family A1

Also known as: DMO, DMRT4

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II and sex differentiation. Predicted to act upstream of or within male mating behavior and ovarian follicle development. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
Pubs (1 yr)
P/LP submissions
P/LP missense
1.17
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.17LOEUF
pLI 0.000
Z-score 1.10
OE 0.69 (0.421.17)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-1.18Z-score
OE missense 1.21 (1.101.33)
307 obs / 254.3 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.69 (0.421.17)
00.351.4
Missense OE?1.21 (1.101.33)
00.61.4
Synonymous OE?1.20
01.21.6
LoF obs/exp: 10 / 14.5Missense obs/exp: 307 / 254.3Syn Z: -1.63

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

DMRTA1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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