DLEU2

Chr 13

deleted in lymphocytic leukemia 2

Also known as: ALT1, BCMSUN, DLB2, LEU2, LINC00022, MIR15AHG, NCRNA00022, RFP2

NCBI Gene: 8847 ENSG00000231607 OMIM: 605766

This gene produces non-coding RNAs that regulate cell proliferation and cell cycle progression. Mutations in DLEU2 are associated with chronic lymphocytic leukemia and other hematologic malignancies, typically involving deletions or epigenetic silencing of the gene region. The inheritance pattern and specific neurological phenotypes associated with DLEU2 mutations are not established in the provided information.

OMIM ResearchSummary from RefSeq

This locus represents a microRNA host gene and also produces long alternatively spliced non-coding RNAs. This genome region was observed to be deleted or epigenetically suppressed in leukemia, and was implicated as a negative regulator of cell proliferation. However, an alternative transcript produced at this locus was also found to promote progression through the cell cycle via angiotensin I converting enzyme 2 and cyclin D1. [provided by RefSeq, Dec 2017]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

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LOEUF

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Mechanism