DLEU2

Chr 13

deleted in lymphocytic leukemia 2

Also known as: ALT1, BCMSUN, DLB2, LEU2, LINC00022, MIR15AHG, NCRNA00022, RFP2

NCBI Gene: 8847ENSG00000231607

This gene produces non-coding RNAs that regulate cell proliferation and cell cycle progression. Mutations in DLEU2 are associated with chronic lymphocytic leukemia and other hematologic malignancies, typically involving deletions or epigenetic silencing of the gene region. The inheritance pattern and specific neurological phenotypes associated with DLEU2 mutations are not established in the provided information.

Summary from RefSeq
Research Assistant →
0
Active trials
10
Pubs (1 yr)
61
P/LP submissions
0%
P/LP missense
—
LOEUF
—
Mechanism
Clinical Summary— DLEU2
📋
ClinVar Variants
61 unique Pathogenic / Likely Pathogenic· 82 VUS of 162 total submissions
Explore recent and relevant literature in Research Assistant →

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

162 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic59
Likely Pathogenic2
VUS82
Likely Benign3
59
Pathogenic
2
Likely Pathogenic
82
VUS
3
Likely Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
59
0
59
Likely Pathogenic
0
0
2
0
2
VUS
0
74
8
0
82
Likely Benign
0
3
0
0
3
Benign
0
0
0
0
0
Total077690146

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

DLEU2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →
Clinical Literature
Open Research Assistant →
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
PubTator3
Top 5 full-text resultsSearch PubTator3 ↗
Key Publications
Landmark & review papers · by relevance
PubMed
Top 5 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
LncRNA Dleu2 regulates fear extinction memory through Celf2-driven synaptic plasticity.
Pi Z et al.·Brain Res Bull
2026
Adult Type Lipoblastoma With a Predominantly Fibroblastic Morphology and a Novel DLEU2::PLAG1 Gene Rearrangement: Two Cases of a Rare Entity.
Steidl T et al.·Genes Chromosomes Cancer
2025Cohort
LncRNA Dleu2 Serve as a Novel Biomarker for Ablation Recurrence and Promote Atrial Remodelling by Targeting Nr4a1 in Atrial Fibrillation.
Wei F et al.·J Cell Mol Med
2025Open AccessFunctional
Alcohol consumption and esophageal cancer risk: unveiling DLEU2 as a key immune modulator through Mendelian randomization and transcriptomic analysis.
Qu K et al.·Discov Oncol
2025Open Access
DLEU2 facilitates bladder cancer progression through miR-103a-2-5p/SOS1 axis.
Liu Y et al.·PeerJ
2025Open Access
Top 5 resultsSearch Europe PMC ↗

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients